Effect of DIGESTIVE+++ and LAMININE on gut health and integrity
Laminine® and DIGESTIVE+++ Supplementation Improves Gut Health as Determined by Pilot Clinical Trial Showing Increased Short Chain Fatty Acids Production in the Colon, Especially Butyrate.
A pilot clinical study was conducted to observe the efficacy of subjects consuming two dietary supplements, Laminine and DIGESTIVE+++ over four weeks. DIGESTIVE+++ dietary supplement contains a prebiotic blend of fructooligosaccharides, Jerusalem Artichoke (90% inulin), Dandelion leaves, and Yacon root.
Additionally, the DIGESTIVE+++ supplement contains the spore-forming probiotic Bacillus coagulans. The product also includes a digestive enzyme blend to digest proteins (at various pHs), carbohydrates, lactose, and fats.
The enzyme blend consists of Amylase, three different Proteases, Alpha-galactosidase, Glucoamylase, Lactase, Invertase, Lipase, Acid Maltase, Peptidase, and Flaxseed oil.
Increased Butyrate Production is Found to be Supportive of Colon Health
Butyrate has been studied for its role in nourishing the colonic mucosa. It is the substrate of choice for colonocytes to increase their healthy functioning.
Butyrate use by colonocytes has been indicated in the regulation of gross mutations in the mucosal cells’ DNA. It led to overgrowths of dysregulated cells, such as in the formation of tumors.
It promotes cell differentiation, cell-cycle arrest, and apoptosis of mutated colonocytes. A more significant increase in SCFA production and delivery, especially butyrate, to the distal colon has been shown to have a protective effect.
Butyrate Supports Normalized Inflammation Response in the Bowel
During the four-week study, an average 28% increase in butyrate production was shown in the subjects. The clinical indication of an increase in butyrate production supports normalized bowel inflammation.
Butyrate is the choice of fuel for the cells lining the colon. When cells lining the gut are adequately nourished and healthy, inflammation is regulated. It provides a more robust gut lining, which helps resist leaking and tears.
In specific imbalances of the colon and GI tract, butyrate has been shown to regulate markers of inflammation. People that experience bowel disturbances and irritation, including those with diarrhea, tend to have lower total SCFAs.
DIGESTIVE+++ contains the probiotic Bacillus coagulants, which remains intact during the digestive process because it is one of the only spore-forming lactobacillus types.
The protective spore helps keep the colonizing bacteria viable through digestion and has been shown in studies to remain in the colon as an effective probiotic.
When the gut is more optimally colonized with good probiotics, the gut lining is improved, gastrointestinal disturbances are minimized, and healthy bowel function is restored.
Supplementing with Laminine and DIGESTIVE+++ dietary supplements from LifePharm showed that Short-Chain Fatty Acids (especially butyrate for the colon) is being increased over a relatively short time.
The formula created by LifePharm for a probiotic, prebiotic, and digestive enzyme product was formulated with science-based trials evaluating each selected ingredient.
Taking DIGESTIVE+++ and Laminine as directed was shown to support the optimal digestive tract and colon health.
The results evaluated differences in the collagen units from baseline and after six months’ use of products. Statistical evaluations (related sample t-tests) showed a highly significant increase in collagen units for the group of 9 subjects and the female group and the male group.
The same was true for the elastin values measured by related samples tested, as all groups showed highly significant or very highly significant increases in elastin units.
The results of the study indicated that applying Lamiderm Apex topically and leaving one application on the face overnight while consuming the dietary supplement Laminine showed highly significant skin improvement in all subjects.